Expert Review of Anti-infective Therapy · 2021 · 18 citations · 22 references
MedicineMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryMolecular PharmacologyAnthelmintic PharmacologyAnthelmintic ResistanceAntiparasitic AgentsAntiparasitic Drug ResistanceAntiparasitic PharmacologyDrug ToxicityAntiparasitic Drug DesignAntiparasitic Drug DiscoveryDrug Discovery For AnthelminticsMolecular Recognition ScaffoldsNovel Antiparasitic Compound ClassesPathogenesis Of SchistosomiasisSchistosomiasis TreatmentSchistosomicidal Agents
BACKGROUND: Treatment and control of schistosomiasis rely on a single drug, praziquantel. New orally active antischistosomals featuring novel molecular scaffolds are urgently needed to prevent the emergence of resistance. METHODS: mouse model. RESULTS: infection. CONCLUSION: antischistosomal activity amenable to chemical modification for drug development.
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The Lancet · 2014 · 2.4K citations · Full text
Simon I Hay, Amanuel Alemu Abajobir, Kalkidan Hassen Abate et al. · The Lancet · 2017 · 2.2K citations · Full text
Public Health, Health Policy, Population Health Sciences +17