Concepedia

Silacyclization through palladium-catalyzed intermolecular silicon-based C(sp<sup>2</sup>)–C(sp<sup>3</sup>) cross-coupling

Ying Qin, Lianghui Li, Jin-Yuan Liang, Kailong Li, Dongbing Zhao

Chemical Science · 2021 · 41 citations · 39 references

DOIFull text

Open access

Concepts

Abstract

]oxepines with good functional group tolerance. The key to success for this reaction is that silicon atoms have a stronger affinity for oxygen nucleophiles than carbon nucleophiles, and silacyclobutanes (SCBs) have inherent ring-strain-release Lewis acidity.

References

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