Agricultural and Biological Chemistry · 1983 · 10 citations · 1 references
AgricultureMedicinal ChemistryWeed ScienceHerbicide ChemistryOrganic ChemistryStructure-activity RelationshipsAromatic PlantsHerbicide Structure-activity RelationshipsHerbicide SynthesisHeterocyclic ChemistryQuantitative Structure-activity RelationshipsStructure-activity Relationship AnalysisPhenyl Ring Substitution EffectsPyrazine ChemistryPyrazole ChemistryStereochemical Structure-activity RelationshipsStructure-activity Relationship Modeling
Sixty six 2, 3-dicyano-5-substituted pyrazines were synthesized and their herbicidal activities against barnyard grass were measured in pot tests to clarify the relationship between chemical structure and activity. The activity of 59 derivatives was related parabolically to the hydrophobic substituent parameter at the 5-position of the pyrazine ring.
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