Advanced Synthesis & Catalysis · 2021 · 19 citations · 54 references
Natural SciencesChemical EngineeringChemistryCatalysisOrganic ChemistryHeterocycle SynthesisCascade ReactionsChalcogenide SynthesisCopper CatalysisMild Reaction ConditionsTriazole ChemistryTriazole Synthesis
Abstract A copper‐catalyzed four‐component cascade reaction for the preparation of triazoles bearing β‐hydroxy chalcogenides from terminal alkynes, azides, epoxides, and Se/K 2 S is reported. The present reaction proceeds under mild conditions, and exhibits a good functional group compatibility. A possible mechanism is proposed. magnified image
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Christian W. Tornøe, Caspar Christensen, Morten Meldal · The Journal of Organic Chemistry · 2002 · 8.5K citations