A small and highly sensitive red/far-red optogenetic switch for applications in mammals

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Lei S. Qi, Matthew H. Larson, Luke A. Gilbert et al. · Cell · 2013 · 5.2K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Millisecond-timescale, genetically targeted optical control of neural activity

Edward S. Boyden, Feng Zhang, Ernst Bamberg et al. · Nature Neuroscience · 2005 · 4.9K citations

Life Sciences, Neurobiology, Neuroscience +12

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

Sergei Zolotukhin, Barry J. Byrne, Emily Grace Mason et al. · Gene Therapy · 1999 · 1.3K citations

Life Sciences, Biotechnology, Molecular Biology +13

Rapid blue-light–mediated induction of protein interactions in living cells

Matthew J. Kennedy, Robert M. Hughes, Leslie A Peteya et al. · Nature Methods · 2010 · 1.2K citations

Natural Sciences, Biophysics, Cell Biology +11

Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds

Jesse G. Zalatan, Michael E. Lee, Ricardo Almeida et al. · Cell · 2014 · 945 citations · Full text

Life Sciences, Bioengineering, Biotechnology +14