Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer

Abstract

E3 ubiquitin-linked enzyme MARCH5, also known as membrane-associated circular finger 5, is an enzyme encoded by the human <i>MARCH5</i> gene. The main objective of this study was to visualize the prognosis of <i>MARCH5</i> in breast cancer and to determine the relationship between <i>MARCH5</i> expression and tumor immunity. MARCH5 expression was significantly higher in several cancers, including breast cancer (BRCA), compared with corresponding normal tissues. Not only was high <i>MARCH5</i> expression associated with poorer overall survival, but also <i>MARCH5</i> expression was positively correlated with the number of tumor-infiltrating immune cells in BRCA malignant tissues. Furthermore, <i>MARCH5</i> expression showed a strong correlation with various immune markers of BRCA, suggesting its role in regulating tumor immunity. MARCH5 is a useful prognostic biomarker in several cancers, and its expression is highly correlated with tumor immune cell infiltration, and increased <i>MARCH5</i> expression may serve as a new biomarker for BRCA diagnosis and prognosis.