Co(<scp>iii</scp>)-catalysed regioselective linear C(8)–H olefination of isoquinolone with terminal aromatic and aliphatic alkynes

Abstract

A regioselective C8 linear olefination of isoquinoline-1<i>H</i>-2-one with terminal (aromatic and aliphatic) alkynes is reported under Co(III) catalysis. This is an exclusive report on the C8 functionalization of isoquinolone using non-noble transition metal complexes. Experimental and computational mechanistic studies have also been performed to depict the reaction pathway.