Non-Genetic Generation of Antibody Conjugates Based on Chemoenzymatic Tyrosine Click Chemistry

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark et al. · Nature Biotechnology · 2008 · 1.4K citations

Pharmacy, Pharmaceutics, Pharmacology +16

Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

Anas Younes, Nancy L. Bartlett, John P. Leonard et al. · New England Journal of Medicine · 2010 · 1.4K citations · Full text

Medicine, Oncology, Pharmacology +17

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

Pavel Strop, Shu‐Hui Liu, Magdalena Dorywalska et al. · Chemistry & Biology · 2013 · 498 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33‐positive acute myeloid leukemia in first recurrence

Richard A. Larson, Eric L. Sievers, Edward A. Stadtmauer et al. · Cancer · 2005 · 458 citations

Medicine, Hematology, Pharmacology +17

Site‐Specific and Stoichiometric Modification of Antibodies by Bacterial Transglutaminase

Simone Jeger, Kurt Zimmermann, Alain Blanc et al. · Angewandte Chemie International Edition · 2010 · 330 citations

Pharmacy, Oncology, Pharmacology +17