P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer - Concepedia

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P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer

DOI Full Paper Access

29

Citations

35

References

2021

Year

Yinwei Cheng, Fa‐Min Zeng, Da‐Jia Li, Shaohong Wang, Jianzhong He, Zhenchang Guo, Ping‐Juan Nie, Zhi‐Yong Wu, Wenqi Shi, Bing Wen,

Cancer Communications

Abstract

Fascin interacts directly with PCAF and is acetylated at lysine 471 in ESCC cells. Fascin-K471 acetylation suppressed ESCC cell migration and tumor metastasis by reducing filopodium formation through the impairment of its actin-bundling activity.

References

	Year	Citations

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