Publication | Open Access
Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy (Adv. Mater. 37/2021)
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2021
Year
NanoparticlesLow‐dose CombinationNanotherapeuticsEngineeringNanotoxicologyChemistryNanomedicineMedicinal ChemistryTherapeutic NanomaterialsToxicologyAnti-cancer AgentRadiation OncologyArsenene NanodotsPlant-derived Anticancer DrugNanotechnologyMedicineArsenical DrugsTumor TargetingPharmacologyDrug TargetingNanomaterialsSelective Killing EffectsPharmaceutical NanotechnologyDrug Delivery SystemsOncologyDrug Discovery
Arsenical Drugs In article number 2102054, Aiguo Wu, Tian Xie, Wei Tao, and co-workers reveal PEGylated arsenene nanodots (AsNDs@PEG) with high monoelemental arsenic purity and negligible systemic toxicity as a new-concept arsenical drug. This AsNDs@PEG, when applied in a low-dose combination strategy with β-elemene, a plant-derived anticancer drug, achieves synergistic therapeutic outcomes.