MedicineMolecular BiologyOncologyCarcinogenesisGene ExpressionMolecular OncologyCancer BiomarkersHepatocellular CarcinomaLiver CancerMicrorna-mediated RegulationNoncoding Rna In CancerRna InterferenceCircular Rna FunctionCircular Rna RegulationCircular RnasHepatocellular Carcinoma PathogenesisMicrorna Function In CancerMicrorna In CancerProtein Expression LevelsWestern Blotting
was detected using xenograft assay. Our results showed that circNFIX was remarkably up-regulated in HCC and was associated with a poor survival. Knockdown of circNFIX repressed proliferation, invasion and glutaminolysis of HCC cells. Moreover, circNFIX directly sponged miR-3064-5p to release HMGA2 expression, and thus conferred the malignant development of HCC. In conclusion, circNFIX serves as a competing endogenous RNA to accelerate HCC progression via regulating miR-3064-5p/HMGA2 axis, suggesting a therapeutic strategy for HCC intervention.