Formulation, Development and Evaluation of in-situ Periodontal Gel Containing Ofloxacin

Abstract

In-situ gel forming formulations are a novel concept of providing drugs to individuals as a liquid dosage form yet achieving sustained release of the drug for the required duration. Different polymer based distribution schemes have been created that can boost the residence time of the product at the drug absorption location. These formulations exist as a flowing system before administration and at the physiological environment it gets converted into viscoelastic gel. The available therapies are to minimize the bacterial infection and to regenerate the damage done by infection and inflammation. The therapies involve systemic therapy, conventional therapy, as well as local therapy. Aim of the present work was to formulate in-situ gel of ofloxacin and it is evaluated for antibacterial activity and stability and it showed good antibacterial activity for both gram positive and gram negative microorganisms and was stable at refrigerated temperature over three months. The results indicated that the formulation could be utilized to maintain the localized drug concentration for a longer period and increase patient compliance with lesser adverse effects.