Effect of a new modified polyamidoamine dendrimer biomimetic system on the mineralization of type I collagen fibrils: an in vitro study

Abstract

We evaluate the effects of the new Dentine matrix protein 1 (DMP-1) biomimetic system composed of phosphorylated polyamidoamine dendrimer (PAMAM-PO₃H₂) and carboxylated polyamidoamine dendrimer (PAMAM-COOH) on the mineralization of type I collagen fibrils. PAMAM-PO₃H₂ and PAMAM-COOH were observed to have the ability to induce internal and external mineralization of type I collagen fibrils <i>in vitro</i> through non-classical mineralization crystallization pathway, which has become a hopeful biomimetic system of biomimetic remineralization and demineralization of dentin type I collagen fibrils and has great potential in inducing biomimetic remineralization of demineralized dentin.