The antiviral action of the RIG-I induced pathway of apoptosis (RIPA) is enhanced by its ability to degrade Otulin, which deubiquitinates IRF3

Linear ubiquitination prevents inflammation and regulates immune signalling

Björn Gerlach, Stefanie M. Cordier, Anna C. Schmukle et al. · Nature · 2011 · 912 citations

Inflammation, Immunology, Immune Regulation +5

A ubiquitin ligase complex assembles linear polyubiquitin chains

Takayoshi Kirisako, Kiyoko Kamei, Shigeo Murata et al. · The EMBO Journal · 2006 · 779 citations · Full text

Protein Assembly, Natural Sciences, Molecular Biology +3

Structural Insights into RNA Recognition by RIG-I

Dahai Luo, Steve C. Ding, Adriana Vela et al. · Cell · 2011 · 407 citations

Functional Genomics, Rna Recognition, Rna Structure Prediction +5

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

Rune Busk Damgaard, Jennifer A. Walker, Paola Marco‐Casanova et al. · Cell · 2016 · 336 citations · Full text

The tumour suppressor CYLD is a negative regulator of RIG‐I‐mediated antiviral response

Constantin S Friedman, Marie Anne O’Donnell, Diana Legarda‐Addison et al. · EMBO Reports · 2008 · 325 citations · Full text

Tumour Suppressor Cyld, Negative Regulator, Immunology +8