Comparison of the Relative Diagnostic Performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT for the Detection of Bone Metastasis in Patients With Different Cancers

Abstract

[⁶⁸Ga]Ga-DOTA-FAPI-04 PET/CT exhibits excellent diagnostic performance as a means of detecting bone metastases, and is superior to [¹⁸F]FDG PET/CT in this diagnostic context. Furthermore, [⁶⁸Ga]Ga-DOTA-FAPI-04 tracer uptake levels are higher than those of [¹⁸F]FDG for most bone metastases. However, owing to the potential for false-positive bone lesions, it is critical that physicians interpret all CT findings with caution to ensure diagnostic accuracy.