The Effect of Multidomain Interventions on Global Cognition, Symptoms of Depression and Apathy — A Pooled Analysis of Two Randomized Controlled Trials

Abstract

We found no conclusive evidence that multidomain interventions reduce the risk of global cognitive decline, symptoms of depression or apathy in a mixed older population. Our results suggest that these interventions may be more effective in those with lower baseline cognitive functioning. Extended follow-up for dementia occurrence is important to inform on the potential long-term effects of multidomain interventions.