Investigation of the Relationship among Cortisol, Pro-inflammatoryCytokines, and the Degradation of Tryptophan into Kynurenine inPatients with Major Depression and Suicidal Behavior

Abstract

These findings show that both cortisol and proinflammatory cytokines are involved in the enhanced breakdown of Trp into Kyn occurring in suicidal MDD patients, thus adding new knowledge on the biological mechanisms leading to the activation of the Kyn pathway in MDD and suicide.