FBXO10 prevents chronic unpredictable stress‐induced behavioral despair and cognitive impairment through promoting RAGE degradation

Abstract

FBXO10 administration prevents CUS-induced behavioral despair, cognitive impairment, neuroinflammation, and the polarization of microglia through decreasing the accumulation of RAGE, p38 MAPK, and NF-κΒ, suggesting potential therapeutic strategies for the prevention and treatment of depression.