Catalyst‐Free and Oxidant‐Free Cascade Difluoroalkylation and Controllable C−F Bond Activation of Aryl Enol Acetates for the Synthesis of β‐Fluoroenones and β‐Enaminones

Abstract

Abstract Aryl enol acetates and DMF could promote radical difluoroalkylation of aryl enol acetates to generate α,α‐difluoro‐γ‐ketoacetates without a catalyst, an oxidant, or a base. When using different bases, β‐fluoroenones and β‐enaminones were synthesized by controllable C−F bond activation. These transformations provide an alternative method for the cascade difluoroalkylation and C−F bonds activation of aryl enol acetates. magnified image