Residual homing of α4β7-expressing β1 <sup>+</sup> PI16 <sup>+</sup> regulatory T cells with potent suppressive activity correlates with exposure-efficacy of vedolizumab - Concepedia

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Residual homing of α4β7-expressing β1 <sup>+</sup> PI16 <sup>+</sup> regulatory T cells with potent suppressive activity correlates with exposure-efficacy of vedolizumab

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Citations

33

References

2021

Year

Emily Becker, Mark Dedden, Christine M. Gall, Maximilian Wiendl, Arif B. Ekici, Anja Schulz-Kuhnt, Anna Schweda, Caroline Voskens, Ahmed N. Hegazy, Francesco Vitali,

Abstract

Completely blocking T<sub>Eff</sub> cell trafficking with vedolizumab, while simultaneously permitting residual homing of powerful T<sub>Reg</sub> cells in an optimal 'therapeutic window' based on target exposure levels might be a strategy to optimise treatment outcomes in patients with IBD.

References

	Year	Citations

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