The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons

Abstract

Selective deletion of AnxA1 in DRG neurons enhances TRPV1 sensitivity and deteriorates noxious heat or capsaicin induced nociception, while ANXA1 mimic peptide Ac2-26 desensitizes TRPV1 via FPR2 and the downstream PLCβ-Ca²⁺-CaM signal. This study may provide possible target for developing new analgesic drugs in inflammatory pain.