Effects of ligustrazine on the expression of neurotransmitters in the trigeminal ganglion of a rat migraine model

Abstract

Our results demonstrated that ligustrazine had potent activity against NTG-induced migraine rats through inhibition of the c-fos/ERK signaling pathway. This work may provide a comprehensive basis for a better understanding of the pathogenesis of migraine and the curative mechanisms of ligustrazine.