Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα⁺ mesenchymal progenitors

Abstract

Pim1 knockout exerted protective effects in sarcopenia by inhibiting the adipogenic differentiation of PDGFRα⁺ mesenchymal progenitors induced by C/EBPδ activation and thus reducing the intramuscular adipose tissue content in aging mice. These results provide a potential target for the treatment of sarcopenia.