Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of <i>Adamts10</i>

Abstract

Adamts10G661R/G661R mice recapitulate the short stature and ocular phenotypes of WMS. The altered fibrillin-1 and fibrillin-2 immunoactivity in Adamts10G661R/G661R mice suggests that the G661R mutation of Adamts10 perturbs regulation of the fibrillin isotype composition of microfibrils in the mouse eye.