Straightforward Stereoselective Synthesis of Seven-Membered Oxa-Bridged Rings through <i>In Situ</i> Generated Cycloheptenol Derivatives

Abstract

An iodine-mediated stereoselective synthesis of seven-membered oxa-bridged rings via <i>in situ</i> generated cycloheptenols was reported. This process was realized through the combination of C-C σ-bond cleavage and C-O bond-forming reactions in a one-pot fashion from simple and easily accessible raw materials. The formation of carbon radicals initiated by I₂ was the key to the reaction.