Emergence and Genetic Characterization of Plasmid-Encoded VIM-2-Producing Pseudomonas stutzeri with Novel Integron In1998 Isolated from Cerebrospinal Fluid

Abstract

A novel <i>bla</i> _VIM-2-carrying conjugative plasmid, pZDHY95-VIM-2, was reported for the first time in <i>P. stutzeri</i>, elucidating the genetic environment and transfer mechanism. The gene structure of the novel class I integron In<i>1998</i> was also clarified. We explored the phylogenetic relationship of <i>P. stutzeri</i> with drug resistance genes and suggested that <i>Pseudomonas</i> with metallo-β-lactamases (MBLs) in the hospital environment may cause infection in patients with long-term intubation or after interventional surgery.