Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia

Abstract

The results show that anti-PF4/polyanion IgG-mediated thrombus formation in VITT patients is accompanied by a massive innate immune activation and particularly the fulminant activation of neutrophils including NETosis. These results provide novel data on the immune response in this rare adenoviral vector-induced VITT.