Suppression of joint pain in transient receptor potential vanilloid 4 knockout rats with monoiodoacetate-induced osteoarthritis

Masahiko Soga, T Izumi, Isamu Nanchi, Narumi Horita, Miyuki Yamamoto, Shiori Kawasaki, Koichi Ogawa, Masahide Fujita, Yasuhide Morioka

PAIN Reports · 2021 · 18 citations · 27 references

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Abstract

Transient receptor potential vanilloid 4 was sensitized in the DRG neurons of MIA rats and played a critical role in the development of OA pain. These results suggest that the inhibition of TRPV4 might be a novel potent analgesic strategy for treating OA pain.

References

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