Copper(<scp>ii</scp>) mediated <i>ortho</i> C–H alkoxylation of aromatic amines using organic peroxides: efficient synthesis of hindered ethers

Abstract

Synthesis of hindered alkyl aryl ether derivatives (R-O-Ar) remains a huge challenge and highly desirable in organic and medicinal chemistry because extensive substitution on the ether bond prevents the undesired metabolic process and thus avoids rapid degradation <i>in vivo</i>. Herein, we report an unprecedented hindered alkoxylation of picolinamide attached aromatic amines using economic copper salt and organic peroxide to get highly desirable α-tertiary alkyl aryl ethers.