Concepedia

QT Interval Prolongation in People Treated With Bedaquiline for Drug-Resistant Tuberculosis Under Programmatic Conditions: A Retrospective Cohort Study

Sharon Isralls, Kathy Baisley, Eric Ngam, Alison D. Grant, James Millard

Open Forum Infectious Diseases · 2021 · 32 citations · 15 references

Open access

Abstract

We observed a modest prolongation of QTcF, maximal at week 15; there were no recorded arrhythmias or related deaths.

References

15

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

Andreas H. Diacon, Alexander S. Pym, Martin P. Grobusch et al. · New England Journal of Medicine · 2009 · 836 citations · Full text

Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline

Andreas H. Diacon, Alexander S. Pym, Martin P. Grobusch et al. · New England Journal of Medicine · 2014 · 732 citations · Full text

Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis

Alexander S. Pym, Andreas H. Diacon, Shenjie Tang et al. · European Respiratory Journal · 2015 · 333 citations · Full text

Diurnal pattern of QTc interval: How long is prolonged?

János Molnár, Feng Zhang, Jerry Weiss et al. · Journal of the American College of Cardiology · 1996 · 310 citations

Short-term Variability, Sleep, Qtc Interval +1

Effect of bedaquiline on mortality in South African patients with drug-resistant tuberculosis: a retrospective cohort study

Kathryn Schnippel, Norbert Ndjeka, Gary Maartens et al. · The Lancet Respiratory Medicine · 2018 · 259 citations

Retrospective Cohort Study, Pulmonary Tuberculosis, South African Patients +12