Surface Modifications of Superparamagnetic Iron Oxide Nanoparticles with Polylactic Acid-Polyethylene Glycol Diblock Copolymer and Graphene Oxide for a Protein Delivery Vehicle

Abstract

As a protein delivery vehicle, superparamagnetic iron oxide nanoparticles (SPION) with an average size of 19.6 4.8 nm were coated with polylactic acid (PLA) (5000)-polyethylene glycol (PEG) (10000) diblock copolymer and single layer graphene oxide (GO). Bovine serum -1 albumin was selected as the model protein, and the drug loading capacity of the designed vehicle is 2013 79 mg g . The drug release result shows that the average percentage of cumulative drug release after 47 days in vitro is 37.7% 1.4%.