<i>κ</i> Opioid Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO‐1 Pathway and Regulating Ca²⁺‐SERCA2a

Abstract

<i>κ</i>-OR agonists U50488H can improve ERS in cardiomyocytes and relieve myocardial injury in HF rats through activating the Nrf2/HO-1 pathway and regulating Ca²⁺-SERCA2a to inhibit Ca²⁺ influx.