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A Pilot Randomized Clinical Trial: Oral Miltefosine and Pentavalent Antimonials Associated With Pentoxifylline for the Treatment of American Tegumentary Leishmaniasis

Sofia Sales Martins, Daniel Holanda Barroso, Bruna Côrtes Rodrigues, Jorgeth de Oliveira Carneiro da Motta, Gustavo Subtil Magalhães Freire, Ledice Inácia de Araújo Pereira, Patrícia Shu Kurisky, Ciro Martins Gomes, Raimunda Nonata Ribeiro Sampaio

Frontiers in Cellular and Infection Microbiology · 2021 · 19 citations · 11 references

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Abstract

In this pilot randomized clinical trial, M+P treatment and A+P treatment yielded similar cure rates, and the former was associated with a lower risk of AEs. Future studies with more patients and longer follow-up are recommended.

References

11

Oral Miltefosine for Indian Visceral Leishmaniasis

Shyam Sundar, T. K. Jha, C.P. Thakur et al. · New England Journal of Medicine · 2002 · 771 citations · Full text

Miltefosine for New World Cutaneous Leishmaniasis

Jaime Soto, Byron Arana, Julia Toledo et al. · Clinical Infectious Diseases · 2004 · 379 citations

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Miltefosine in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis in Brazil: A Randomized and Controlled Trial

Paulo Roberto Lima Machado, Julia S. Ampuero, Luiz Henrique Guimarães et al. · PLoS neglected tropical diseases · 2010 · 246 citations · Full text

Interventions for Old World cutaneous leishmaniasis

Urbà González, Mariona Pinart, Ludovic Revéiz et al. · Cochrane Database of Systematic Reviews · 2008 · 167 citations

Randomized Controlled Clinical Trial to Access Efficacy and Safety of Miltefosine in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania (Viannia) guyanensis in Manaus, Brazil

Anette Chrusciak‐Talhari, Reynaldo Dietze, Carolina Talhari et al. · American Journal of Tropical Medicine and Hygiene · 2011 · 161 citations · Full text