Cp^<i>x</i>M(<scp>iii</scp>)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes

Abstract

Cp^xM(iii)-catalyzed enantioselective C-H functionalization reactions have progressed rapidly using either chiral cyclopentadienyl ligands or appropriate chiral carboxylic acids. In this context, highly reactive carbene and nitrene precursors can serve as effective C-H coupling partners, providing a straightforward and efficient approach to access chiral molecules. In this review, we highlight the developments in Cp^xM(iii)-catalyzed enantioselective C-H functionalization reactions through migratory insertion of metal-carbenes/nitrenes by employing chiral Cp^xM(iii) complexes or achiral Cp^xM(iii) complexes combined with chiral carboxylic acids.