Structure-Based Designing, Solvent Less Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carboxylate Derivatives: A Combined In Vitro and In Silico Screening Approach

Abstract

After combined experimental and virtual screening <b>5c</b>, <b>5g</b> and <b>5e</b> could serve as lead compounds, having low IC₅₀ and high binding affinity.