Novel ETV1 mutation in small cell lung cancer transformation resistant to EGFR tyrosine kinase inhibitors

Abstract

Novel <i>ETV1</i> p.E462Q and p.P159S mutations were found in the SCLC tissues of TKIs-resistant LUAD patients, providing a new understanding of <i>ETV1</i> involvement in acquired resistance to <i>EGFR</i>-TKIs via SCLC transformation.