Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents

Abstract

Discussion | In this study, initial vaccine-elicited neutralizing antibody titers were negatively associated with age, resulting in a diminished ability to neutralize SARS-CoV-2 in vitro. Neutralizing titers against P.1 were reduced across all ages, although the magnitude of the age-dependent difference was smaller. Interim clinical trial data did not identify age as a contributing factor to overall vaccine efficacy. 1 However, recent studies in vaccinated populations have found a measurable increase in COVID-19 cases among vaccinated older adults. 3,4 The data from the current study are consistent with neutralizing antibody levels playing an important role in this observation.