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Non-HLA Antibodies and Epitope Mismatches in Kidney Transplant Recipients With Histological Antibody-Mediated Rejection

DOIFull Paper Access

51

Citations

47

References

2021

Year

Marta Crespo, Laura Llinàs-Mallol, Dolores Redondo‐Pachón, Carrie Butler, Javier Gimeno, María José Pérez‐Sáez, Carla Burballa, Anna Buxeda, Carlos Arias-Cabrales, Montserrat Folgueiras,
Frontiers in Immunology

Abstract

In conclusion, pre-transplant AT<sub>1</sub>R-Ab is frequently found in ABMR<sub>h</sub>DSA<sub>pos</sub> patients. However, AT<sub>1</sub>R-Ab, MICA-Ab, ETAR-Ab or EC-XM<sup>+</sup> are rarely found among ABMR<sub>h</sub>DSA<sub>neg</sub> patients. Pre-transplant AT<sub>1</sub>R-Ab may act synergistically with preformed or <i>de novo</i> HLA-DSA to produce ABMR<sub>h</sub>DSA<sub>pos</sub> but not ABMR<sub>h</sub>DSA<sub>neg</sub>. HLA epitope mismatch associates with ABMR<sub>h</sub>DSA<sub>pos</sub> compared with ABMR<sub>h</sub>DSA<sub>neg</sub>, suggesting factors other than HLA are responsible for the damage.

References

YearCitations

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