Upregulation of COX-2 and PGE2 Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts - Concepedia

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Upregulation of COX-2 and PGE2 Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts

DOI Full Paper Access

34

Citations

36

References

2021

Year

Chuen‐Mao Yang, Chien-Chung Yang, Li‐Der Hsiao, Chia‐Ying Yu, Hui‐Ching Tseng, Chih‐Kai Hsu, Jiro Hasegawa Situmorang

Journal of Inflammation Research

Abstract

Our results suggested that TNF-α-induced COX-2/PGE<sub>2</sub> upregulation is mediated through TNFR1-dependent MitoROS/PKCα/p38 MAPK and JNK1/2 cascade to activate FoxO1 binding with the COX-2 promoter in HCFs.

References

	Year	Citations

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