Autophagy upregulates inflammatory cytokines in gingival tissue of patients with periodontitis and lipopolysaccharide‐stimulated human gingival fibroblasts

Abstract

Autophagy augmented the production of inflammatory cytokines by mTOR inactivation via the AKT signaling pathway in the gingival tissues of patients with periodontitis and LPS-stimulated HGFs. These findings would provide a better understanding of the mechanism by which autophagy regulates the inflammatory response associated with periodontal pathogenesis.