Intracranial Sonodynamic Therapy With 5-Aminolevulinic Acid and Sodium Fluorescein: Safety Study in a Porcine Model

Abstract

The results of the present study suggest that either Na-FL or 5-ALA-mediated sonodynamic therapies under MRI-guidance with the current acoustic parameters are safe towards healthy brain tissue in a large <i>in vivo</i> model. These results further support growing interest in clinical translation of sonodynamic therapy for intracranial gliomas and other brain tumors.