Brain white matter extracellular free-water increases are related to reduced neurocognitive function in systemic lupus erythematosus

Abstract

The association between WM extracellular FW increases and reduced neurocognitive performance suggest possible microvascular degradation and/or neuroinflammation in SLE patients with clinically inactive disease. The mechanistic impact of cumulative glucocorticoids on WM FW deserves further evaluation.