A covalent organic framework-based nanoagent for H₂S-activable phototherapy against colon cancer

Abstract

Herin, we report a Cu(ii)-porphyrin-derived nanoscale COF, which can be triggered by endogenous H₂S via an intracellular sulfidation reaction to generate a metal-free COF-photosensitizer for PDT against H₂S-enriched colon tumors with controllable singlet oxygen release; meanwhile in situ generated CuS can be synchronously used as a photothermal agent for PTT.