High Glucose Activates YAP Signaling to Promote Vascular Inflammation

Abstract

With the current study we demonstrated that YAP signaling is activated by high glucose in endothelial cells <i>in vitro</i> and in the vasculature of diabetic mice, and we pinpointed YAP as a regulator of high glucose-mediated endothelial inflammation and monocyte attachment. YAP inhibition may represent a potential therapeutic opportunity to improve diabetes-associated vascular complications.