Photoredox synthesis of functionalized quinazolines <i>via</i> copper-catalyzed aerobic oxidative C_sp2–H annulation of amidines with terminal alkynes

Abstract

We demonstrate a simple CuCl-catalyzed C–H annulation of amidines with terminal alkynes to form functionalized quinazolines at RT. This photochemical method is a mild process, highly efficient, and practically applicable to the synthesis of anticancer agents.