Cell Cycle · 2021 · 55 citations · 39 references
Life SciencesCardiologyPharmacologyAutophagyGene ExpressionSignal TransductionAtrial FibrillationAutophagy In DiseaseAutophagy ModulationAutophagy RegulationAutophagy Signaling PathwaysFibrosisAtrial Fibrillation MechanismsAtrial Fibrillation PathophysiologyAtrial FibrosisAtrial Structural RemodelingAutophagy In The HeartAutophagy PathwayCardiac Fibrosis ModulationLysosomal Degradation Pathways
studies, we found that Que can effectively inhibit the expression of miR-223-3p in AF model cells and rats myocardial tissues, and meanwhile enhance the expression of FOXO3 and activate the autophagy pathway, and significantly inhibit myocardial fibrosis, and improve myocardial remodeling in atrial fibrillation. All in all, in this study, we found that Que prevents isoprenaline-induced MF by increasing autophagy via regulating miR-223-3p/FOXO3.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PubMed · 1997 · 66.6K citations