Synthesis of 2-aminobenzofurans <i>via</i> base-mediated [3 + 2] annulation of <i>N</i>-phenoxy amides with <i>gem</i>-difluoroalkenes

Abstract

Efficient metal-free [3 + 2] annulation of <italic>N</italic>-phenoxy amides with <italic>gem</italic>-difluoroalkenes has been realized for the assembly of 2-aminobenzofuran derivatives with potent cytotoxicity against cancer cell lines and application potential for DELs.