Deletion of SarX Decreases Biofilm Formation of Staphylococcus aureus in a Polysaccharide Intercellular Adhesin (PIA)-Dependent Manner by Downregulating spa

Abstract

<i>sarX</i> promoted biofilm production of <i>S. aureus</i> that may primarily be mediated through increasing <i>ica</i> operon expression and PIA production. Furthermore, deletion of <i>sarX</i> reduced <i>S. aureus</i> biofilm formation by downregulating <i>spa</i>.