Organic Letters · 2021 · 53 citations · 44 references
Natural SciencesChemical EngineeringChemistryCatalysisElectrochemistryOrganic ChemistryCross-coupling ReactionsIndustrial Catalytic ProcessesMechanochemistryMetal CatalysisAryl Halide CouplingBall MillingCatalytic Cycle MechanismsCross-coupling CatalysisCross-electrophile CouplingNickel CatalysisNickel-catalyzed Cross-couplingReductive Cross-coupling
The nickel-catalyzed cross-electrophile coupling of aryl halides and alkyl halides enabled by ball-milling is herein described. Under a mechanochemical manifold, the reductive C-C bond formation was achieved in the absence of bulk solvent and air/moisture sensitive setups, in reaction times of 2 h. The mechanical action provided by ball milling permits the use of a range of zinc sources to turnover the nickel catalytic cycle, enabling the synthesis of 28 cross-electrophile coupled products.
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