Microwave‐Assisted Biosynthesis of CuO Nanoparticles Using <i>Atalantia monophylla</i> (L.) Leaf Extract and its Biomedical Applications

Abstract

Abstract The facile and rapid biosynthesis of copper oxide nanoparticles (AM‐CuONPs) using Atalantia monophylla leaves extract under microwave irradiation is investigated. Optical and structural characterizations confirm the synthesis of spherical to rod‐shaped phase pure AM‐CuONPs. The antibacterial activity of AM‐CuONPs is higher with Gram‐positive bacteria compared to Gram‐negative bacteria. The antioxidant potential of AM‐CuONPs is reflected in radical scavenging activities in a concentration‐dependent manner, tested by 2,2‐diphenyl‐1‐picrylhydrazyl and 3‐ethylenebenzothiazoline‐6‐sulfonic acid diammonium salt assay. The promising anticancer activity of AM‐CuONPs is observed by killing ∼80 % of HeLa cells without affecting normal human embryonic kidney cells. The results reveal the potential of biosynthesized AM‐CuONPs for antibacterial, antioxidant, and anticancer applications.